Endocrine Abstracts

Introduction: Cushing’s disease (CD) leads to glucose homeostasis alterations, obesity, unfavorable changes in body composition and cardiovascular complications.Aim of study: i) Prospective evaluation of the frequency of pre-diabetes and diabetes. ii) Assessment of insulin resistance (IR) indices in CD. iii) Analysis of the influence of family history of type 2 diabetes (T2D) on the anthropometry in CD.Methods: The study group...

Introduction: Cortisol excess in Cushing’s disease (CD) leads to glucose homeostasis alterations and increased cardiovascular risk.Aim of the study: i) To assess the reversibility of glucose homeostasis alterations and dynamics of inflammatory and coagulation parameters after the successful transsphenoidal surgery (TSS) for CD. ii) Analysis of the early improvement in insulin resistance (IR) indices following TSS.Methods: The ...

Introduction: Bilateral adrenalectomy (BA) is rarely applied as a therapeutic procedure. It serves as a life-saving treatment in patients with persistent Cushing’s disease after an ineffective pituitary surgery or in ectopic ACTH production. Other indications for BA are: bilateral adrenocortical adenomas, congenital adrenal hyperplasia and bilateral phaeochromocytoma in patients with hereditary paraganglioma-phaeochromocytoma (PPS/PGL) syndromes. It is also a procedure of...

Introduction: Hyponatremia occurs in 33–69% of women with postpartum pituitary necrosis. The aim of the study was to present a patient in whom recurrent hyponatremia was one of the dominant symptoms of postpartum anterior pituitary hormones deficiency.A case report: 55-year-old woman with a diagnosis of Sheehan syndrome established 19 years after the last labor complicated by massive bleeding due to uterine atonia. The first symptoms of pituitary in...

Introduction: Women with Turner syndrome (TS) have a 13-year reduction in life expectancy compared to the general population. Cardiovascular disease (CVD), whether congenital or acquired, is the cause of death in around half of these women. Therefore, early identification of congenital heart defects, aortic abnormalities and risk factors for CVD is extremely important, and may have a significant impact on long-term outcomes of CVD in TS.Aim and methods: ...

Background: Craniopharyngiomas may lead to pituitary insufficiency and neurological symptoms. However the rate of the tumor growth and the time of developing hypopituitarism are difficult to predict.Case report: A 68-year-old male of short stature (height 148 cm) was admitted to the area hospital due to loss of consciousness. The acute coronary syndrome and stroke had been excluded but laboratory tests showed hyponatremia of 106 mmol/l. Hormone measureme...

Introduction: Brown tumor–well circumscribed lytic lesion is one of the complication of advanced stage of primary and secondary hyperparathyroidism. It may be also a first clinical sign of primary hyperparathyroidism. Nowadays this is rare manifestation in developed countries due to increased use of routine screening laboratory examinations. Brown tumors may also mimic true neoplasm and lead to misdiagnosis if close attention is not paid. We present three case reports and...

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is a multi-glandular autosomal dominant genetic disorder which, most typically, includes medullary carcinoma of the thyroid, pheochromocytoma and primary hyperparathyroidism. The authors present a case study of a young man in whom cardiogenic shock was the first manifestation of pheochromocytoma and MEN2A.Case report: A 30-year-old man without a past history of hypertension or any other chronic m...

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...

Introduction: Survivin is a multifunctional protein and acts as an inhibitor of apoptosis. Its expression occurs in nearly all human cancers. In some tumors survivin expression correlates with the malignant behavior and diminished response to cytotoxic therapy. Data concerning survivin expression in invasive pituitary gland adenomas are contradictory.Patients and methods: Survivin expression was assessed in 38 invasive pituitary gland adenomas (31 non-fu...